Personalizing FVIII dosing based on your unique PK profile

Anyone with hemophilia A should know their PK profile, regardless of what product they use to manage their bleeds.

In Canada, there are two tools your healthcare team can use to measure PK – WAPPS and myPKFiT. Both of these tools have patient-assisted components that work on your smart phone to help you know what your estimated FVIII level is 24/7.

Personal Digital Tools

Learn more about WAPPS and myPKFiT

Understanding your PK profile can be particularly helpful in:

Personalizing your hemophilia A management with your healthcare team

Planning your schedule

Staying active

Feeling confident about your ability to prevent bleeds

Do you know how to get the most out of your treatment?

Pharmacokinetic profiles, otherwise known as “PK profiles,” show what happens to a substance inside the body. For people with hemophilia A, your PK profile can help estimate how long FVIII will stay in your blood after each infusion, and this profile is unique for each person. In a way, your FVIII level is like a rechargeable battery. It can be full on one day, or it can be low and in need of charging up on another day. The level is highest right after an infusion and goes down over time until you get the next infusion.

Sample FVIII PK profiles

FVIII levels after infusion

Day 1 | Morning

The half-life of a substance is the time it takes for half of it to be eliminated from the body. Hypothetical PK profiles following a single 40 IU/kg infusion on the morning of Day 1 in a person with a FVIII half‑life of 12.7 hours (Alex) and a person with a FVIII half‑life of 8.0 hours (Sam). Half‑life varies by individual; the graph is based on an example and is for illustrative purposes only.

Depending on your lifestyle it is important to know where your FVIII level is on any particular day or time.

For more information about PK profiles, check out this video:

As everyone’s PK profile is different, knowing this information is important because it may help your healthcare team personalize your treatment plan to your own PK profile and lifestyle.